event resulting in great loss

CALAMITY
WordClue
BASHgala event
CASEactual event
HARMdamage, loss
TSARPeter the Great
WALLGreat or Hadrian's
GIANTmythical human of very great size
GRIEFresponse to loss
ORDERfungus or stop-loss
WRATHGreat anger
DAMAGEloss, detriment
GATSBYThe Great ... (book)
INJURYloss, ill
AMNESIALoss of memory
BLACKOUTtemporary loss of consciousness
DECREASEloss, drop
DEFERENCEGreat respect
PREDICTIONstatement about an uncertain event
SUPERVISORmanager in a business or event
ASTONISHMENTamazement, great surprise
VULNERABILITYinability to withstand an event
INCIDENTevent or occurrence
BYGONEevent that happened in the past