bitter pill

ANNOYANCE
WordClue
AIMend, proclivity
ENDbitter or dead
BEERale, brew
CUSPsharp point or pointed end
PLANpurpose, end
CURSEscourge, annoyance
LIMITend, terminus
BITTERpale ale
DESIGNaim, end
FINISHthe end of anything
STREETdead-end or one-way
TABLETpill
COUPLETpair of lines with rhyming end words
DIVORCEend of a marital union
PASSINGthe end of something
PURPOSEend, design
ETERNITYExistence without end, infinite time
SEDATIVEsleeping pill
TERMINUSThe end or final point of something
EXTINCTIONend of an organism
ENDbitter or dead
GRIEFbitterness, suffering