adversity, dolour

TROUBLE
WordClue
WOEtrouble, bewilderment
CAREtrouble, anxiety
EVILcalamity, trouble
FUSStrouble, torment
PAINtrouble, ado
GRIEFheartbreak, affliction
HOTELHeartbreak ... (Presley)
NAKBAadversity
MISERYadversity, suffering
REGRETgrief, heartbreak
STROKEmisfortune, adversity
REVERSEdisaster, adversity
CALAMITYadversity, reverse
DISASTERadversity, trouble
DISTRESSadversity, ill-luck
REVERSESadversity, affliction
ADVERSITYtrouble, dolour
SUFFERINGadversity, disaster
AFFLICTIONadversity, bad-luck
MISFORTUNEadversity, reverse
TROUBLEadversity, distress
DISTRESSadversity, ill-luck